Dr. Lu received his Ph.D. from Cornell University Medical College. He did his postdoctoral work at Rockefeller University with Paul Greengard and Mu-ming Poo on molecular mechanism of synaptic transmission and development, using the Xenopus neuromuscular synapses as a model system. In 1993, he became a faculty member at Roche Institute of Molecular Biology, where he began studying the role of neurotrophins in synapse development and plasticity. He joined NICHD as an Investigator in 1996. His laboratory investigates the mechanisms underlying neurotrophic regulation of synapses, and their functional significance.
1. Ama"Zinc" Link between TrkB Transactivation and Synaptic Plasticity. Neuron. 2008.
2. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 2004.
3. Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell. 2007.
4. Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms. Cell Biol. 2006.